Protective effect of picroliv, active constituent of Picrorhiza kurrooa, against oxytetracycline induced hepatic damage.
Indian J Exp Biol
;
1997 Dec; 35(12): 1302-5
Article
Dans Anglais
| IMSEAR
| ID: sea-56235
ABSTRACT
Picroliv, the active constituent of P. kurrooa, showed a dose dependent (1.5-12 mg/kg, po for 7 days) hepatoprotective activity against oxytetracycline induced hepatic damage in rat. It increased the number of viable hepatocytes (ex-vivo) significantly. Increase in bile volume and its contents in conscious rat suggests potent anticholestatic property. Picroliv also antagonised alterations in enzyme levels (GOT, GPT, and alkaline phosphatase) in isolated hepatocytes and serum, induced by oxytetracycline (200 mg/kg, i.p.) feeding. Picroliv was more potent than silymarin a known hepatoprotective drug.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Oxytétracycline
/
Rats
/
Silymarine
/
Acide vanillique
/
Femelle
/
Mâle
/
Extraits de plantes
/
Cinnamates
/
Hétérosides
/
Inde
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1997
Type:
Article
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