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Toxic effects of different concentrations of dimethoate on lysosomal enzymes of female albino rats.
Indian J Exp Biol ; 1992 May; 30(5): 394-8
Article de En | IMSEAR | ID: sea-56408
The effect of three different concentrations of dimethoate on the activity of certain lysosomal enzymes, viz. beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin B and cathepsin D in serum, skin, liver, kidney and spleen and the stability of liver and kidney lysosomes was studied in female albino rats. The activity of beta-glucuronidase, beta-N-acetylglucosaminidase, cathepsin D was found to increase in serum and tissues in higher concentration (2.25 mg/100 g body weight) of dimethoate treated rats. A significant increase in the rate of release of beta-glucuronidase was found in the liver and kidney of higher concentration of dimethoate treated rats compared to controls. The results demonstrate that the activity of lysosomal enzymes increased in higher concentration of dimethoate treated rats than the lower concentration (0.56 mg/100 g body weight) of dimethoate treated rats.
Sujet(s)
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Rats / Peau / Viscères / Femelle / Rat Wistar / Diméthoate / Relation dose-effet des médicaments / Animaux / Lysosomes langue: En Texte intégral: Indian J Exp Biol Année: 1992 Type: Article
Texte intégral: 1 Indice: IMSEAR Sujet Principal: Rats / Peau / Viscères / Femelle / Rat Wistar / Diméthoate / Relation dose-effet des médicaments / Animaux / Lysosomes langue: En Texte intégral: Indian J Exp Biol Année: 1992 Type: Article