Reversal of T-cell unresponsiveness through serine-esterase inhibitors mediated enhanced lymphokine induced microbicidal activities in kala-azar.
Indian J Exp Biol
;
1992 Jan; 30(1): 54-6
Article
Dans Anglais
| IMSEAR
| ID: sea-56724
ABSTRACT
After presenting processed glycoprotein of Leishmania donovani to T-cell, macrophage seeks the help of a panel of T-cells lymphokines to transform from a state that sustains intra cellular replication of parasite to an effector state for destructing parasites. But esterase and trypsin of macrophage membrane prevent T-cells to release MIF. Role of soya-bean trypsin inhibitor (STI) has been exposed in the present study with a view to alter esterase functional behaviour of macrophage for control of T-cell activation and also, if T-cells once made responsive to antigen by STI do alter macrophage response to T-cells or not. Results establish STI as potent effector molecule, which can serve as an adjuvant to candidate T-cell epitope and synthetic peptide for development of anti-Kala-azar vaccine protocol in future.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Inhibition de la migration cellulaire
/
Activation des lymphocytes
/
Lymphocytes T
/
Inhibiteurs trypsiques
/
Cytotoxicité immunologique
/
Relation dose-effet des médicaments
/
Immunité cellulaire
/
Leishmaniose viscérale
/
Activation des macrophages
/
Macrophages
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1992
Type:
Article
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