Female gonadal sex steroids potentiate the anti-convulsant activity of phenytoin sodium.
Indian J Exp Biol
;
1998 Jul; 36(7): 713-5
Article
Dans Anglais
| IMSEAR
| ID: sea-57055
ABSTRACT
Neither estrogen (E), progesterone (P), E + P nor phenytoin could protect the rats against maximal electroshock seizure. However phenytoin administration in the E, P, or E + P pre-treated animals provided significant protection in terms of absence of hind limb extension and a decrease in the extension/flexion ratio. The results suggest that there is an existing beneficial influence of the oral contraceptives both individually and in combination on the anti-convulsant activity of phenytoin, and this needs to be further probed.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phénytoïne
/
Progestérone
/
Rats
/
Stéroïdes
/
Femelle
/
Rat Wistar
/
Évaluation préclinique de médicament
/
Synergie des médicaments
/
Oestrogènes
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1998
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS