Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.
Indian J Exp Biol
;
2001 Apr; 39(4): 339-43
Article
Dans Anglais
| IMSEAR
| ID: sea-57237
ABSTRACT
A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the doses of 100 and 200 mg/kg, po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid induced writhing methods were used to asses analgesic activity. Indomethacin (20 mg/kg, ip) was used as the standard anti-inflammatory drug. Pentazocine (10 mg/kg, ip) and aspirin (25 mg/kg, ip), both clinically used analgesics, were used as standard analgesics for comparison. IHp extract showed significant anti-inflammatory and analgesic activity at both dose levels, in all the paradigms used. Additionally, IHp potentiated the anti-inflammatory activity of indomethacin and analgesic activities of pentazocine and aspirin.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pentazocine
/
Plantes médicinales
/
Rats
/
Femelle
/
Mâle
/
Extraits de plantes
/
Granulome à corps étranger
/
Anti-inflammatoires non stéroïdiens
/
Acide acétylsalicylique
/
Seuil nociceptif
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2001
Type:
Article
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