IDPH-8261--a new nonsteroidal antiinflammatory agent.
Indian J Exp Biol
;
1995 Jan; 33(1): 28-33
Article
Dans Anglais
| IMSEAR
| ID: sea-57540
ABSTRACT
IDPH-8261, methyl alpha-methyl-4-(3-thienyl)benzeneacetate, exhibited marked anti-inflammatory activity in acute, subacute and chronic models of inflammation. In rats, IDPH-8261 exhibited a dose related inhibition of carrageenin-induced rat paw edema and the inhibition was greater than ibuprofen, phenylbutazone, but was three times less than indomethacin. It exhibited anti-inflammatory activity in normal and adrenalectomized rats. It also exhibited the activity against various phlogistic agents. IDPH-8261 exhibited AI activity in subacute granuloma tests. In adjuvant-induced established polyarthritis. IDPH-8261 exhibited anti-arthritic effect at a very low dose (ED50 = 4 mg/kg, p.o.). Ulcerogenic liability was the lowest (UD50 = 180 mg/kg, p.o.), when compared to reference standard drugs. Low toxicity and high efficacy may make this compound a potentially useful therapeutic agent.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phénylacétates
/
Rats
/
Ulcère
/
Carragénane
/
Anti-inflammatoires non stéroïdiens
/
Chiens
/
Oedème
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1995
Type:
Article
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