Modulation of serum cortisol by substance P in albino rats: evidence of a direct effect on adrenal gland.
Indian J Exp Biol
; 2006 Feb; 44(2): 163-4
Article
de En
| IMSEAR
| ID: sea-57697
Effect of prolonged administration of substance P on the plasma cortisol level in the albino rats has been investigated. An inhibitory impact on intact individuals and a stimulatory effect in pharmacologically annulled rats has been observed. It is concluded that in normal conditions substance P presumably acts as a preventive agent for any excess secretion of cortisol while during stress or disturbed HPA or RAS conditions, it stimulates the secretion of cortisol. An intraglandular modulatory role of substance P has been suggested.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Rats
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Stress physiologique
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Hydrocortisone
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Substance P
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Glandes surrénales
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Agents neuromédiateurs
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Axe hypothalamohypophysaire
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Injections sous-cutanées
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Animaux
langue:
En
Texte intégral:
Indian J Exp Biol
Année:
2006
Type:
Article