Pulmonary phospholipid changes induced by butylated hydroxy toluene, an antioxidant, in rats.
Indian J Exp Biol
;
1995 Oct; 33(10): 796-7
Article
Dans Anglais
| IMSEAR
| ID: sea-57714
ABSTRACT
Butylated hydroxy toluene (BHT), 800 mg/kg body weight, dissolved in corn oil and administered (ip) in a single injection to male rats, damaged the lung as indicated by an increase in lavage ACE, protein and LDH and caused a significant increase in phospholipid, particularly, phosphatidyl choline (PC) in lung lavage and extracellular surfactant. The plasma lecithin cholesterol acyl transferase (LCAT) activity was inhibited leading to an increase in serum phospholipids and phosphatidyl choline. The results indicate that BHT-induced lung phospholipidosis may be attributed to an increase in surfactant phospholipids and/or due to the leakage of plasma phospholipids through damaged capillary membrane.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phospholipides
/
Rats
/
Mâle
/
Butylhydrotoluène
/
Rat Wistar
/
Additifs alimentaires
/
Poumon
/
Animaux
/
Antioxydants
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1995
Type:
Article
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