Correlation of fragile sites and bleomycin induced chromosome break points.
Indian J Exp Biol
;
1989 May; 27(5): 442-4
Article
Dans Anglais
| IMSEAR
| ID: sea-57792
ABSTRACT
Bleomycin (Blm) induced break points in human chromosome preparations were compared with the known fragile sites. A total of 136 breaks were observed from 100 well spread G-banded plates (1.3 bps/cell). These correspond to a total of 57 break prone sites. Of these 57 sites, 24 correspond to the known fragile sites, 5 to sites of protooncogenes and neoplasia, 26 sites correspond to more than one known site of fragility, protooncogene, neoplasia or reciprocal translocation sites, and 2 unknown sites. The findings suggest that fragile sites, either commonly expressed or induced, might be a predisposing factor for chromosome aberrations in human. The expression of fragile sites induced by Blm and their correlation with the known cancer chromosome break points, oncogenes and reciprocal translocation, suggest that the fragile sites are prone to mutagenic action.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Bléomycine
/
Humains
/
Fragilité des chromosomes
/
Chromosomes humains
/
Sites fragiles de chromosome
/
Caryotypage
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1989
Type:
Article
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