Effect of anthelmintics and phenothiazines on adenosine 5'-triphosphatases of filarial parasite Setaria cervi.
Indian J Exp Biol
;
1990 Mar; 28(3): 245-8
Article
Dans Anglais
| IMSEAR
| ID: sea-57931
ABSTRACT
S. cervi showed particulate bound Ca2+ ATPase and Na+,K(+)-ATPase activities while Mg2+ ATPase was detected in traces. ATPase of S. cervi was also differentiated from the nonspecific p-nitrophenyl phosphatase activity. Female parasite and microfilariae exhibited higher Ca2+ ATPase and Na+,K(+)-ATPase activities than the male adults and the enzyme Na+,K(+)-ATPase was mainly concentrated in the gastrointestinal tract of the filarial parasite. Na+,K(+)-ATPase of the filariid was ouabain-sensitive while Ca2(+)-ATPase activity was regulated by concentration of Ca2+ ions and inhibited by EGTA. Phenothiazines, viz. trifluoperazine, promethazine and chlorpromazine caused significant inhibition of Ca2+ ATPase and Na+,K(+)-ATPase. Diethylcarbamazine was a potent inhibitor of these ATPases. Mebendazole, levamisole and centperazine also caused significant inhibition of the ATPases indicating this enzyme system as a common target for the action of anthelmintic drugs.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phénothiazines
/
Infection à Setaria
/
Femelle
/
Mâle
/
Ca(2/) Mg(2/)-ATPase
/
Calcium-Transporting ATPases
/
Adenosine triphosphatases
/
Sodium-Potassium-Exchanging ATPase
/
Filarioidea
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1990
Type:
Article
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