Effect of masheri, a pyrolysed tobacco product on carcinogen metabolizing enzymes.
Indian J Exp Biol
;
1989 Aug; 27(8): 692-4
Article
Dans Anglais
| IMSEAR
| ID: sea-58168
ABSTRACT
Studies on the modulation of the carcinogen metabolizing enzymes on treatment with masheri extract (ME) and benzo (a) pyrene (B (a)P), were carried out in male Sprague Dawley rats (12 weeks old) fed a nutritionally adequate standard diet. Injection (ip) of ME and B (a) P at 3/4 LD50 dose given in 3 doses at 24 hr interval increased the phase I activating enzymes, viz. cytochrome P-450, benzo (a) pyrene hydroxylase and benzphetamine demethylase while both ME and B (a) P significantly depleted glutathione content and decreased glutathione-S transferase activity. Furthermore, the same treatment of ME and B (a) P significantly depleted the hepatic vitamin A pool while a concommittant increase in vitamin C content was observed.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Oxidoreductases, (N-demethylating)
/
Rats
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Lignées consanguines de rats
/
Benzo[a]pyrène
/
Mâle
/
Extraits de plantes
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Aryl hydrocarbon hydroxylases
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Benzopyrene hydroxylase
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Cytochrome P-450 enzyme system
/
Foie
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1989
Type:
Article
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