Isonicotinic acid hydrazide inhibits cell population growth during teratogenesis of chick embryo.
Indian J Exp Biol
;
1991 Jan; 29(1): 12-5
Article
Dans Anglais
| IMSEAR
| ID: sea-58658
ABSTRACT
In chick embryos treated with a 4 hr pulse of 7.2 X 10(-5) M isonicotinic acid hydrazide (INH) the cell population growth is inhibited with an increased population doubling time. Teratogenised blastoderm cells complete their ongoing cell cycle and arrest in G1 phase. A chase with an equimolar concentration of pyridoxal-5-phosphate restores the growth rate after a lag of 4 hr equivalent to the duration of treatment with INH. Presumptive mesoblast cells invaginated through the primitive streak and neuroectoblast cells induced prior to the application of INH differentiate, while the teratogen inhibits morphogenesis and organization of organ primordia.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phosphate de pyridoxal
/
Tératogènes
/
Différenciation cellulaire
/
Division cellulaire
/
Embryon de poulet
/
Isoniazide
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1991
Type:
Article
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