Involvement of potassium channels in hypoglycemic effect of sertraline.
Indian J Exp Biol
;
2006 Feb; 44(2): 120-2
Article
Dans Anglais
| IMSEAR
| ID: sea-58901
ABSTRACT
Effect of 21 days administration of sertraline (30 mg/kg, po) in streptozotocin (55 mg/kg, ip) induced diabetic and non-diabetic rats produced hypoglycemia in diabetic and non-diabetic rats. Pinacidil (1mg/kg, po), when co-administered with sertraline or glimepiride antagonized the decrease in glucose levels in diabetic rats. Pinacidil (10(-6)-10(-3) M) produced dose dependent relaxation (EC50-1.58 x 10(-5) M). Neither sertraline nor glimepiride had any effect on the resting tension of ileum preparation. Both sertraline and glimepiride antagonized competitively the pinacidil-induced relaxation. The pA2 values of sertraline and glimepiride reversal of pinacidil-induced relaxation were 5.5 and 6.2 respectively. These studies suggest the involvement of K+ channels in hypoglyceimic effects of sertraline.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Sulfonylurées
/
Vasodilatation
/
Vasodilatateurs
/
Canaux potassiques
/
Rat Wistar
/
Streptozocine
/
Pinacidil
/
Sertraline
/
Diabète expérimental
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2006
Type:
Article
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