Enhancer aided in vitro permeation of atenolol and prazosin hydrochloride through mice skin.
Indian J Exp Biol
;
2001 Jan; 39(1): 47-51
Article
Dans Anglais
| IMSEAR
| ID: sea-59413
ABSTRACT
Effect of penetration enhancers were studied on the permeation of antihypertensive drugs prazosin hydrochloride and atenolol through full thickness skin of swiss albino mice. Atenolol was delivered to skin from saturated alcoholic solution containing 5% of 1-decanol and alcohol alone, while prazosin hydrochloride was saturated in dimethyl formamide(DMF, 5% v/v in water) and dimethyl sulfoxide(DMSO, 5% v/v in water). Atenolol permeation was augmented significantly in decanolic solution and also in pure alcohol. In case of prazosin hydrochloride, significant enhancement of permeation was shown by DMSO but not by DMF.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Aténolol
/
Absorption cutanée
/
Administration par voie cutanée
/
Prazosine
/
Diméthylsulfoxyde
/
N,N-Diméthyl-formamide
/
Éthanol
/
Alcools gras
/
Animaux
/
Souris
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2001
Type:
Article
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