Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.
Indian J Exp Biol
;
2002 Mar; 40(3): 277-81
Article
Dans Anglais
| IMSEAR
| ID: sea-59955
ABSTRACT
Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. The improved bioavailability is reflected in various pharmacokinetic parameters viz. tmax, Cmax, t(1/2) and AUC, of these antibiotics. The increased bioavailability could be attributed to the effect of piperine on microsomal metabolising enzymes or enzymes system.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pipéridines
/
Rats
/
Femelle
/
Mâle
/
Biodisponibilité
/
Céfadroxil
/
Céfotaxime
/
Interactions médicamenteuses
/
Alcaloïdes
/
Benzodioxoles
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2002
Type:
Article
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