Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.
Indian J Exp Biol
;
1994 Jun; 32(6): 405-8
Article
Dans Anglais
| IMSEAR
| ID: sea-60011
ABSTRACT
Experimental myositis was induced in guinea pigs by multiple inoculations with Myosin B fraction of the rabbit skeletal muscle. Quantitative histopathological features were studied and they include necrosis, central nucleation, inflammatory cellular reaction. Besides myositis, features of myocarditis were evident in 40% animals. Circulating immune complexes (CICs) in the sera of experimental animals were isolated by a polyethylene glycol (PEG) precipitation method. Presence of antimyosin B antibody in the immune complexes was characterised by an enzyme-linked immunosorbent assay. The role of circulating immune complexes in pathogenesis of experimental myositis and human polymyositis have been emphasised.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Mâle
/
Myosines
/
Immunisation
/
Muscles squelettiques
/
Cochons d'Inde
/
Animaux
/
Microscopie
/
Myosite
/
Complexe antigène-anticorps
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1994
Type:
Article
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