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Antinociceptive effect of amitriptyline in mice of acute pain models.
Indian J Exp Biol ; 2007 Jun; 45(6): 529-31
Article Dans Anglais | IMSEAR | ID: sea-60128
ABSTRACT
Tricyclic antidepressant drugs induce antinociceptive effect and suggest that their analgesic action could be related to the monoaminergic activity of the drugs. The analgesic activity of amitriptyline was observed in mouse models of acute pain. Mice were divided into different groups and were given amitriptyline in different doses alone and in combination with morphine. Reaction time in Hot-Plate and Tail-Flick tests was observed. Results showed that amitriptyline had antinociceptive effect in acute pain state in experimental models. Amitriptyline in combination with morphine had better analgesic effect than the morphine alone in Hot-Plate test.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Douleur / Maladie aigüe / Analgésiques non narcotiques / Modèles animaux de maladie humaine / Relation dose-effet des médicaments / Amitriptyline / Animaux / Souris Type d'étude: Études d'évaluation langue: Anglais Texte intégral: Indian J Exp Biol Année: 2007 Type: Article

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Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Douleur / Maladie aigüe / Analgésiques non narcotiques / Modèles animaux de maladie humaine / Relation dose-effet des médicaments / Amitriptyline / Animaux / Souris Type d'étude: Études d'évaluation langue: Anglais Texte intégral: Indian J Exp Biol Année: 2007 Type: Article