Identification and characterization of receptor for dengue virus-induced macrophage cytotoxin.
Indian J Exp Biol
;
1996 Jul; 34(7): 652-7
Article
Dans Anglais
| IMSEAR
| ID: sea-60364
ABSTRACT
The present study was undertaken to identify the receptor for dengue virus type 2 (DV) induced macrophage cytotoxin (CF2) on mouse peritoneal macrophages (MPhi). The binding of 125I-labelled CF2 to MPhi was saturable (15 nM), reversible, temperature, pH- and time-dependent. The saturation concentration was similar to that causing cell death. Scatchard analysis showed the presence of intermediate type of affinity receptor and the number of receptor sites was 1.1 x 10(6) per cell with dissociation constant of 14.28 nM.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Récepteurs viraux
/
Macrophages péritonéaux
/
Cytotoxines
/
Virus de la dengue
/
Animaux
/
Souris
/
Lignées consanguines de souris
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1996
Type:
Article
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