Expression of mu-opioid receptors in developing rat spinal cord: an autoradiographic study.
Indian J Exp Biol
;
2004 May; 42(5): 533-7
Article
Dans Anglais
| IMSEAR
| ID: sea-60546
ABSTRACT
The expression of mu-opioid receptors in the developing rat spinal cord (Postnatal days 7, 14, 30) was studied by autoradiography using [3H]DAMGO. When compared to camera lucida drawings, the receptor was noted over the entire gray matter and dorsal root ganglia at postnatal days 7 and 14. At postnatal day 30, the receptor expression decreased over the gray matter except the superficial laminae (laminae I and II). At all age groups studied, a higher expression of the receptor was noted over the superficial laminae. The study shows that micro-opioid receptors appears early in postnatal development and attains mature receptor distribution relatively late in ontogeny, suggesting a possible role in the normal development of nervous system. This is affirmed by an impairment of psychomotor development in babies born to mothers, addicted to opiates.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Moelle spinale
/
Autoradiographie
/
Facteurs temps
/
Rat Wistar
/
Récepteur mu
/
Animaux
/
Modèles anatomiques
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2004
Type:
Article
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