Effects of alpha-1 adrenergic receptor antagonist, terazosin, on cardiovascular functions in anaesthetised dogs.
Indian J Exp Biol
;
2004 Dec; 42(12): 1195-9
Article
Dans Anglais
| IMSEAR
| ID: sea-60741
ABSTRACT
Initially a dose-response curve of phenylephrine was constructed at dose strengths of 1-16 microg/kg in a cumulative manner. Phenylephrine caused a significant rise in the mean arterial pressure, left ventricular systolic pressure, left ventricular contractility, stroke volume and a significant decline in the heart rate. Terazosin was administered in three selected doses of 10, 100 and 300 microg/kg. Following each dose of terazosin, dose-response curve of phenylephrine was constructed. Terazosin, per se, decreased the basal mean arterial pressure, left ventricular systolic pressure, left ventricular contractility and stroke volume significantly in a dose dependent manner with an increase in the heart rate with no significant change in the cardiac output. The baroreflex sensitivity at all the three doses remained unchanged. In conclusion, the present findings support the view that terazosin reduces the blood pressure in a physiologically more favorable manner by maintaining the neural integrity of the cardiovascular system.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phényléphrine
/
Débit systolique
/
Pression sanguine
/
Mâle
/
Prazosine
/
Phénomènes physiologiques cardiovasculaires
/
Fonction ventriculaire gauche
/
Baroréflexe
/
Antagonistes alpha-adrénergiques
/
Chiens
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2004
Type:
Article
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