Anti-inflammatory properties of 3-methylpyrazolin-5-(4 H)-one-4-[3'-methoxy-4' (2'',3'',4'',6''-tetra-O-acetyl-beta-D-glycopyranosyl]benzylidene (compound IIIA).
Indian J Exp Biol
;
1994 Aug; 32(8): 544-7
Article
Dans Anglais
| IMSEAR
| ID: sea-60951
ABSTRACT
Oral treatment of compound IIIA exhibited dose related inhibitory action in acute tests of carrageenan, histamine and dextran-induced oedema in rats. Marked inhibitory action of the compound was found when it was administered intraperitoneally in animals. It displayed prominent anti-arthritic activity in chronic tests of adjuvant and formaldehyde-induced arthritis in rats. It prevented the arthritis associated rise in total leucocyte count and erythrocyte sedimentation rate. It also lowered the levels of exudate volume and migration of leucocytes in carrageenan induced pleurisy in rats. It did not exhibit any analgesic, antipyretic or ulcerogenic effect. No mortality was recorded up to 2 g/kg in mice on oral or intraperitoneal treatment over a period of 72 hr.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Lignées consanguines de rats
/
Composés benzylidéniques
/
Femelle
/
Mâle
/
Anti-inflammatoires non stéroïdiens
/
Pyrazolones
/
Animaux
/
Souris
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1994
Type:
Article
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