Your browser doesn't support javascript.
loading
Species difference in intestinal drug metabolising enzymes in mouse, rat and hamster and their inducibility by masheri, a pyrolysed tobacco product.
Indian J Exp Biol ; 1991 Mar; 29(3): 256-8
Article Dans Anglais | IMSEAR | ID: sea-61216
ABSTRACT
Activities of several drug metabolising enzymes in the small intestine were investigated in Swiss mice, Sprague Dawley rats and Syrian Golden Hamsters fed 10% masheri, a pyrolysed tobacco product, in diet, for 20 months. The basal levels of enzymes in proximal (PI), medium (MI) and distal (DI) parts of the intestine in the three species were similar. However, the levels of cytochrome P-450, benzo(a) pyrene hydroxylase (B(a)OH) and glutathione S-transferase (GST) were highest in hamsters followed by rat and mice. Upon treatment with masheri, significant induction of cytochrome P-450 and B(a)PH was observed in PI and DI of all the three species. However, GSH and GST was depleted upon masheri treatment in all the three species again only in proximal and distal parts of the intestine. Thus increase in activating enzymes together with depletion in GSH-GST system upon exposure could be an important factor in the susceptibility of the small intestine to hazardous xenobiotic exposure.
Sujets)
Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Végétaux toxiques / Rats / Lignées consanguines de rats / Spécificité d'espèce / Nicotiana / Mâle / Extraits de plantes / Cricetinae / Mesocricetus / Mixed function oxygenases langue: Anglais Texte intégral: Indian J Exp Biol Année: 1991 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: IMSEAR (Asie du Sud-Est) Sujet Principal: Végétaux toxiques / Rats / Lignées consanguines de rats / Spécificité d'espèce / Nicotiana / Mâle / Extraits de plantes / Cricetinae / Mesocricetus / Mixed function oxygenases langue: Anglais Texte intégral: Indian J Exp Biol Année: 1991 Type: Article