Glutathione level and its relation to radiation therapy in patients with cancer of uterine cervix.
Indian J Exp Biol
;
1999 Sep; 37(9): 859-64
Article
Dans Anglais
| IMSEAR
| ID: sea-61541
ABSTRACT
Glutathione functions as an important antioxidant in the destruction of hydrogen peroxide and lipid peroxides by providing substrate for the glutathione peroxidase and also promotes the ascorbic acid. Glutathione plays a vital role in detoxification of xenobiotics, carcinogens, free radicals and maintenance of immune functions. The study was aimed to determine plasma glutathione as well as erythrocyte glutathione and glutathione peroxidase in patients with invasive cervical carcinoma (n = 30) before initiation and after completion of radiotherapy and subsequently, at the time of first three monthly follow-up visit. The levels of plasma glutathione, erythrocyte glutathione and glutathione peroxidase activity were found to be lower in all cervical cancer patients as compared to age matched normal control women. The study indicates a change in antioxidant status in relation with the glutathione system among patients with invasive carcinoma of the uterine cervix. This study also demonstrates the effect of radiation therapy on this antioxidant system.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Tumeurs du col de l'utérus
/
Adulte
/
Érythrocytes
/
Glutathion
/
Glutathione peroxidase
/
Adulte d'âge moyen
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1999
Type:
Article
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