Role of calcium in induction of dengue virus-specific helper T cells.
Indian J Exp Biol
;
1995 Nov; 33(11): 809-15
Article
Dans Anglais
| IMSEAR
| ID: sea-61581
ABSTRACT
Dengue type 2 virus (DV) induces the generation of T helper cells (TH) in the mouse spleen. These TH on adoptive transfer to DV primed syngeneic mice enhance the clonal expansion of antigen-specific antibody plaque forming cells. The present study was undertaken to investigate the role of M phi and Ca2+ in the induction of DV-specific TH. The results show that M phi are obligatory for the induction of DV-specific TH. It was observed that DV antigen stimulate the influx of calcium ion (Ca2+) into T cells as shown by radiolabelled (45Ca) and the influx of Ca2+ increases with time of incubation, reaching a maximum level after 1 hr of incubation. The proliferation of T cells was found to be dependent on presence of Ca2+ as it was inhibited by Ca channel blocking drugs and in the absence of Ca in the medium. Thus showing that Ca2+ plays an important role in the induction of DV-specific TH cells.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Inhibiteurs des canaux calciques
/
Activation des lymphocytes
/
Calcium
/
Immunothérapie adoptive
/
Lymphocytes T auxiliaires
/
Virus de la dengue
/
Animaux
/
Macrophages
/
Souris
/
Lignées consanguines de souris
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1995
Type:
Article
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