Effect of pH and sodium ions on intestinal uptake of lysine in rats.
Indian J Exp Biol
;
1993 Jun; 31(6): 529-32
Article
Dans Anglais
| IMSEAR
| ID: sea-61584
ABSTRACT
Intestinal uptake of lysine in rats progressively decreased with an increase in pH from 5.2 to 8.5, both in the presence and absence of Na+ ions. At pH 5.2 lysine uptake was 30-35% more than that at neutral pH. Na+ activated lysine uptake by 40-50% at pH 5.2 and it was increased to 110-120% at neutral pH. The observed increase in lysine uptake in response to Na+ and H+ gradients was due to enhanced maximal velocity (Vmax), with little change in affinity constant (Kt). Arrhenius analysis revealed a biphasic curve for lysine uptake with transition temperature (Tc) around 20 degrees C (24 degrees C at pH 5.2 in presence of Na+). The energy of activation (Ea) below (16.1-23.4 Kcal/mole) and above (6.7-8.6 Kcal/mole) the Tc was similar at pH 5.2 and 7.0 both in the presence and absence of Na+ ions. The sensitivity of lysine uptake to various inhibitors was also dependent upon pH and Na+ ions.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Sodium
/
Mâle
/
Rat Wistar
/
Antiport des ions sodium-hydrogène
/
Composés du sodium
/
Arsénites
/
Acide iodo-acétique
/
Dinitrophénols
/
N-Éthyl-maléimide
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1993
Type:
Article
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