Mechanism of blood sugar lowering by a swerchirin-containing hexane fraction (SWI) of Swertia chirayita.
Indian J Exp Biol
; 1993 Feb; 31(2): 178-81
Article
de En
| IMSEAR
| ID: sea-61872
Mechanism of blood sugar lowering by the crude/impure swerchirin (SWI) isolated from the hexane fraction of Swertia chirayita was investigated. Single oral administration of SWI (50 mg/kg, body wt) to fed CF rats induced about 60% (max.) fall in blood glucose by 7 hr post-treatment. This was associated with marked depletion of aldehyde-fuchsin stained beta-granules and immunostained insulin in the pancreatic islets. In vitro, glucose uptake and glycogen synthesis by muscle (diaphragm) was significantly enhanced by the serum of SWI-treated rat. At 100, 10 and 1 microM final concentration, SWI greatly enhanced glucose (16.7 mM)-stimulated insulin release from isolated islets. It is therefore concluded that SWI lowers blood glucose level by stimulating insulin release from islets of Langerhans.
Texte intégral:
1
Indice:
IMSEAR
Sujet Principal:
Plantes médicinales
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Rats
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Xanthènes
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Glycémie
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Mâle
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Ilots pancréatiques
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Xanthones
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Hexanes
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Hypoglycémiants
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Animaux
langue:
En
Texte intégral:
Indian J Exp Biol
Année:
1993
Type:
Article