Suppression of steroidogenesis in mice granulosa cells by a synthetic nonapeptide fragment of human seminal plasma inhibin.
Indian J Exp Biol
;
1991 Oct; 29(10): 897-9
Article
Dans Anglais
| IMSEAR
| ID: sea-62282
ABSTRACT
A synthetic nonapeptide, which is C-terminal sequence of 94-amino acid of prostatic inhibin peptide was tested for progesterone and estrogen secretion by mouse granulosa cell cultures. Nonapeptide suppressed the progesterone and estrogen synthesis, the magnitude of suppression was highest at 5 ng dose level for progesterone and 50 ng dose level for estradiol. The study suggests that, nonapeptide exerts its effect by impairing the binding of FSH to granulosa cell receptors.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Fragments peptidiques
/
Progestérone
/
Hormones sexuelles stéroïdiennes
/
Femelle
/
Cellules cultivées
/
Gonadotrophine équine
/
Relation dose-effet des médicaments
/
Hormone folliculostimulante
/
Cellules de la granulosa
/
Inhibines
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1991
Type:
Article
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