Effect of graded doses of methysergide on basal and pentagastrin stimulated gastric secretion in anaesthetised rats.
Indian J Exp Biol
;
1996 Feb; 34(2): 115-7
Article
Dans Anglais
| IMSEAR
| ID: sea-62480
ABSTRACT
The effect of continuous infusion (iv) of graded doses of methysergide (0.1-50 microgram(s)/kg/hr) was studied on basal and pentagastrin (5 microgram(s)/kg/hr) stimulated gastric acid secretion in anaesthetised rats by the slow, continuous stomach perfusion method. Both basal and pentagastrin stimulated acid secretion indicated a biphasic response. Methysergide induced stimulation at a lower dose of 1 microgram(s)/kg/hr and inhibition at higher doses of 20-50 microgram(s)/kg/hr. The stimulatory effect may be due to postsynaptic receptor blockade while the inhibitory effect at higher dose may be due to blockade of presynaptic 5-HT autoreceptors, or due to a direct inhibitory effect of unknown basis.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pentagastrine
/
Rats
/
Antisérotonines
/
Métabolisme basal
/
Femelle
/
Mâle
/
Relation dose-effet des médicaments
/
Muqueuse gastrique
/
Anesthésiques
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1996
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS