Modification of radiosensitivity of chlorpromazine with biological metal ions in Thiobacillus ferrooxidans.
Indian J Exp Biol
;
1999 Dec; 37(12): 1245-7
Article
Dans Anglais
| IMSEAR
| ID: sea-62750
ABSTRACT
Effect of chlorpromazine with biological metal ions, viz. calcium, magnesium, zink and copper was studied on T. ferrooxidans cell system. Chlorpromazine, calcium and magnesium alone could produce radioprotection. Maximum radioprotection was exhibited by chlorpromazine at lower concentration while copper and zink offered radiosensitization. However, combination of chlorpromazine with all biological metal ions exhibited radiosensitization. Dose modifying factor by chlorpromazine at lower concentration (0.025 mM) was 0.754 while in combination with Ca2+, Mg2+, Cu2+ and Zn2+ was 1.08, 1.25, 1.37 and 1.389 respectively. The possible interaction between chlorpromazine and biological metal ions is discussed at cellular membrane level.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Radioprotecteurs
/
Radiosensibilisants
/
Thiobacillus
/
Membrane cellulaire
/
Chlorpromazine
/
Interactions médicamenteuses
/
Métaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1999
Type:
Article
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