Tri-ortho-cresyl phosphate induced neurotarget esterase inhibition in brain and peripheral nerve effectively monitored by lymphocytes.
Indian J Exp Biol
;
1994 May; 32(5): 356-9
Article
Dans Anglais
| IMSEAR
| ID: sea-63033
ABSTRACT
Tri-ortho-cresyl phosphate ester (TOCP 10-100 mg/kg)--an organophosphorus compound (OP) inhibited brain, peripheral nerve and lymphocyte neurotarget esterase activities in a dose related and time-dependent manner. There was a good correlation of inhibition between brain, peripheral nerve and lymphocyte tissues taken from adult hens treated with 3 different doses of TOCP and sacrificed 24 and 48 hr after exposure. The results suggest that lymphocyte can effectively monitor OP compounds for investigating inhibition of neurotarget esterase activity in brain and peripheral nerve tissues.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Nerfs périphériques
/
Tritolylphosphates
/
Encéphale
/
Femelle
/
Carboxylic ester hydrolases
/
Lymphocytes
/
Poulets
/
Surveillance des médicaments
/
Animaux
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
1994
Type:
Article
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