Effect of repeated intraperitoneal exposure to picrotoxin on rat liver lysosomal function.
Indian J Exp Biol
;
2004 Aug; 42(8): 808-11
Article
Dans Anglais
| IMSEAR
| ID: sea-63113
ABSTRACT
Effect of repeated (20 days) exposure to picrotoxin (PTX) on rat liver lysosomal function was evaluated by measuring the free and total activities of acid phosphatase, cathepsin D, ribonuclease II (RNAse II) and deoxyribonuclease II (DNAse II). The free activities of the nucleases (both RNAse II and DNAse II) were increased following PTX exposure. The total DNAse II activity was increased by 2.2-fold whereas the total acid phosphatase activity was decreased by 28%. Consequently, the ratios of total activity / free activity were low in the PTX exposed groups, implying loss of membrane integrity. Cathepsin D activity was completely abolished. The results show that repeated exposure to PTX can lead to lysosomal dysfunction in liver.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Picrotoxine
/
Rats
/
Acid phosphatase
/
Mâle
/
Cathepsine D
/
Convulsivants
/
Endodeoxyribonucleases
/
Exoribonucleases
/
Injections péritoneales
/
Foie
langue:
Anglais
Texte intégral:
Indian J Exp Biol
Année:
2004
Type:
Article
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