Evaluation of endoscopy-based diagnostic methods for the detection of Helicobacter pylori.
Article
Dans Anglais
| IMSEAR
| ID: sea-64453
ABSTRACT
BACKGROUND:
Helicobacter pylori is an etiological factor in duodenal ulcer. Few studies have objectively assessed the accuracy of diagnostic methods for the detection of H. pylori.METHODS:
The sensitivity and specificity of histology, touch smear, rapid urease test (RUT) and brush cytology of endoscopic antral biopsy from patients with duodenal ulcer were compared. Forty-nine patients were evaluated before, and 34 after, eradication therapy. Each time, sampling was done for all 4 tests. The infection status for each sample was established by a positive concordance of results of three of four tests.RESULTS:
The highest degree of agreement was between RUT and cytology (kappa = 0.69). Brush cytology (100%) followed by RUT (94.5%) were the most sensitive tests. Histology had the highest specificity (89.3%). A combination of RUT or brush cytology with histology had the maximum chance of detecting H. pylori. As single tests, brush cytology and touch smear had high diagnostic accuracies with a Youdin J value of 1.79 and 1.78, respectively.CONCLUSION:
The best method for diagnosis of H. pylori is a combination of the rapid urease test or brush cytology with histology. Brush cytology or touch smear are diagnostic tests of choice if a single test is desired.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Urée
/
Biopsie
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Valeur prédictive des tests
/
Études prospectives
/
Helicobacter pylori
/
Infections à Helicobacter
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
langue:
Anglais
Année:
2000
Type:
Article
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