Alpha-1 antitrypsin deficiency among Indian children with liver disorders.
Article
Dans Anglais
| IMSEAR
| ID: sea-65050
ABSTRACT
AIMS:
To determine the frequency of alpha-1 antitrypsin (AAT) deficiency in children with chronic liver disease (CLD) and neonatal cholestasis syndrome (NCS).METHODS:
All children with NCS (n=23) or CLD (n=35) attending the Pediatric Gastroenterology Clinic between November 2003 and July 2005 were screened for AAT deficiency using phenotyping through isoelectric focusing of plasma.RESULTS:
Of the 58 children studied, 57 had normal PiMM phenotype. One child with CLD had the M1E type of normal variant. None of the patients had the abnormal phenotype PiZZ.CONCLUSION:
AAT deficiency is infrequent among children with CLD and NCS in our region.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Phénotype
/
Temps de prothrombine
/
Humains
/
Céruloplasmine
/
Nouveau-né
/
Enfant
/
Enfant d'âge préscolaire
/
Cholestase
/
Déficit en alpha-1-antitrypsine
/
Alanine transaminase
Pays comme sujet:
Asie
langue:
Anglais
Année:
2006
Type:
Article
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