Prevalence of celiac disease among siblings of celiac disease patients.
Article
Dans Anglais
| IMSEAR
| ID: sea-65558
ABSTRACT
AIMS:
To determine the prevalence of celiac disease (CD) in siblings of patients with this disease in Punjab, where wheat is the staple diet.METHODS:
Families of 80 patients with CD diagnosed as per modified ESPGAN criteria were offered family screening. Their siblings aged 2-15 years were tested for serum IgA anti-tissue transglutaminase antibody (anti-tTG) antibody. Those with positive or borderline test and some of those with negative test underwent endoscopic duodenal biopsy. Siblings with characteristics histological findings and showing improvement on follow-up were labeled as having celiac disease.RESULTS:
Of the 63 siblings of 48 index cases studied, 15 tested positive for anti-tTG; of these 13 had celiac disease. Three tested borderline for anti-tTG; none of them had CD. Of the 45 anti-tTG-negative subjects, two agreed to undergo biopsy; one of these had features of CD. Overall, 14 of 63 (22%) siblings had CD, including 8 who had no symptoms suggestive of CD.CONCLUSIONS:
CD is common among siblings of patients with CD in Punjab and may be asymptomatic.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Maladie coeliaque
/
Enfant
/
Enfant d'âge préscolaire
/
Risque
/
Prévalence
/
Adolescent
/
Fratrie
Type d'étude:
Etude d'étiologie
/
Étude de prévalence
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Année:
2006
Type:
Article
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