Antibodies to Cag A protein are not predictive of serious gastroduodenal disease in Indian patients.
Article
Dans Anglais
| IMSEAR
| ID: sea-65746
ABSTRACT
OBJECTIVE:
The present study was aimed at assessing the predictive utility of anti-Cag A antibodies in differentiating patients of duodenal ulcer (DU) and non ulcer dyspepsia (NUD) from asymptomatic controls in a developing country.METHODS:
Sera from 120 subjects were tested for antibodies to Cag A using the immunodominant portion of a recombinant 37.5 kDa fusion protein by ELISA, in endoscopically proven cases of DU and NUD and healthy controls.RESULTS:
The observed optical density (OD) in DU and NUD patients was 1,947 and 1,960 respectively, which was higher than that observed in controls (p < 0.01), but there was no difference in the anti-Cag A antibody titers between DU and NUD patients.CONCLUSION:
Anti-Cag A antibodies do not seem to discriminate duodenal ulcer patients from non ulcer dyspepsia in the Indian population.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Protéines bactériennes
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Test ELISA
/
Études cas-témoins
/
Prévalence
/
Valeur prédictive des tests
/
Courbe ROC
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Année:
1998
Type:
Article
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