Serum hyaluronic acid concentrations in children with cirrhosis.
Article
Dans Anglais
| IMSEAR
| ID: sea-65764
ABSTRACT
BACKGROUND:
Liver disease is associated with increased levels of hyaluronic acid (HA).AIM:
To evaluate serum HA concentrations in children with cirrhosis and its relation with liver function tests and Child-Pugh score.METHODS:
Twenty-two children with biopsy-proven liver cirrhosis were studied. All were assessed for the presence of ascites or encephalopathy and liver function tests were performed. Patients were categorized according to Child-Pugh criteria. Serum HA was measured using microELISA (normal 0-100 ng/mL). Twenty-two children with chronic hepatitis B and no cirrhosis were studied as controls.RESULTS:
Serum HA level in the cirrhotic children was 85.2 (72.8) ng/mL; levels were high (166.0 [46.3] ng/mL; range 115-246) in 8 (36.4%) patients. Three of 11 (27.2%) Child-Pugh class A patients, 3 of 8 (37.5%) class B patients, and 2 of 3 (66.7%) class C patients had elevated serum HA values (p=ns). Serum HA levels correlated with direct bilirubin level. The control group had lower levels (4.8 [2.3] ng/mL; p< 0.05), which were in the normal range.CONCLUSION:
Serum HA level may be useful as a diagnostic tool in children with cirrhosis.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pronostic
/
Valeurs de référence
/
Ponction-biopsie à l'aiguille
/
Indice de gravité de la maladie
/
Femelle
/
Humains
/
Mâle
/
Marqueurs biologiques
/
Études cas-témoins
/
Enfant
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
langue:
Anglais
Année:
2004
Type:
Article
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