Prevalence of renal involvement in Indian patients with systemic sclerosis.
Indian J Med Sci
;
2007 Feb; 61(2): 91-6
Article
Dans Anglais
| IMSEAR
| ID: sea-67627
ABSTRACT
BACKGROUND:
Renal involvement in systemic sclerosis (SSc) either in the form of scleroderma renal crisis (SRC) or nonrenal crisis abnormalities has been reported to be in the range of 60-80%. Renal involvement is thought to be rare in Indian patients with SSc. However, there is paucity of data.AIMS:
To study the frequency and pattern of renal involvement in Indian patients with SSc. SETTINGS ANDDESIGN:
A single center prospective, cross sectional study. MATERIALS ANDMETHODS:
We prospectively evaluated the patients with SSc attending the Rheumatology Clinic. All patients were evaluated for renal involvement. All patients underwent measurement of blood pressure, urine examination, glomerular filtration rate (GFR) estimation using Cockcroft-Gault formula and kidney biopsy when indicated. STATISTICALANALYSIS:
Statistical analysis was performed using SAS 8.0 statistical package.RESULTS:
Eighty-seven patients were included in the study from July 2001 to December 2004. Mean age of patients was 36.88 +/- 12.51 years. About 30% of patients had diffuse cutaneous SSc. None of these patients had SRC either at enrollment in the study or during follow-up. Eleven (12.6%) patients had hypertension. Six (6.9%) patients had abnormal urinary findings in the form of either active urinary sediment or significant proteinuria. Only one patient had azotemia (plasma creatinine > 1.8 mg/dl). Calculated GFRCONCLUSION:
SRC is very rare in Indian patients with SSc. However, non-renal crisis abnormalities appear to be as common in Indian patients as compared to the western literature.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Sclérodermie systémique
/
Femelle
/
Humains
/
Mâle
/
Prévalence
/
Études transversales
/
Études prospectives
/
Adulte
/
Inde
/
Défaillance rénale chronique
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Med Sci
Année:
2007
Type:
Article
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