Formulation, evaluation and comparison of gels containing different COX-2 inhibitors.
Indian J Med Sci
;
2001 Oct; 55(10): 549-52
Article
Dans Anglais
| IMSEAR
| ID: sea-68808
ABSTRACT
PG synthesis plays major role in inflammation. The enzymes responsible for PG synthesis are cox-1 and cox-2. Cox-1 regulates physiological functions in gut and kidney while cox-2 induces inflammation. Selective cox-2 inhibitors have little effect on cox-1 and thus showed better GI tolerability. The efficacy of new drugs is not greater than that of NSAID's by oral route of administration. In the present study new selective cox-2 inhibitors also showed less efficacy than NSAID'S by topical route of administration. However if current studies confirm the reduced GI toxicity this can be the only advantage of these drugs because these drugs showed less efficacy than NSAID'S by oral and topical routes of administration.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rats
/
Véhicules pharmaceutiques
/
Chimie pharmaceutique
/
Anti-inflammatoires non stéroïdiens
/
Administration par voie topique
/
Inhibiteurs des cyclooxygénases
/
Prostaglandin-endoperoxide synthases
/
Oedème
/
Cyclooxygenase 2
/
Inhibiteurs de la cyclooxygénase 2
langue:
Anglais
Texte intégral:
Indian J Med Sci
Année:
2001
Type:
Article
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