Clinically unsuspected Hodgkin's lymphoma diagnosed primarily from bone marrow trephine biopsy: report of six cases.
Indian J Pathol Microbiol
;
2008 Apr-Jun; 51(2): 186-9
Article
Dans Anglais
| IMSEAR
| ID: sea-73014
ABSTRACT
Bone marrow may be the initial or rarely the only site of involvement in Hodgkin's lymphoma. A high index of suspicion is required to pick up the histopathological changes of Hodgkin's lesions in the bone marrow like necrosis, presence of Reed-Sternberg cell or its variant in a polymorphic background infiltrate, focal fibrosis and myxoid change especially in the absence of classical clinical picture. Bone marrow with immunohistochemistry has a valuable role in the staging and in the diagnosis of primary medullary Hodgkin's lymphoma. B-symptoms may easily masquerade as an infectious process as in all our cases the patients had fever as a presenting feature, in four of them tuberculosis was suspected clinically and two had received antitubercular therapy elsewhere. We report six human immunodeficiency virus-negative patients diagnosed over a period of 5 years in which the initial diagnosis of Hodgkin's lymphoma was suggested from bone marrow histology.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Moelle osseuse
/
Myélogramme
/
Femelle
/
Humains
/
Mâle
/
Maladie de Hodgkin
/
Immunohistochimie
/
Enfant d'âge préscolaire
/
Études rétrospectives
/
Antigènes CD15
Type d'étude:
Étude observationnelle
langue:
Anglais
Texte intégral:
Indian J Pathol Microbiol
Année:
2008
Type:
Article
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