Incidence of lamivudine resistance associated mutations in pol-gene of HIV-1 in patients from north India: a preliminary report.
Indian J Pathol Microbiol
;
2005 Jul; 48(3): 337-40
Article
Dans Anglais
| IMSEAR
| ID: sea-74485
ABSTRACT
Screening of drug-resistant variants is very important for the effective clinical management of HIV-infected patients and development of new strategies. The present study was aimed to detect codon-184 mutations in the pol-gene of HIV leading to resistance to lamivudine (3-TC) by nested cum ARMS-PCR approach in 10 treated and 9 treatment naive patients. For correlation the whole blood CD4/CD8 cell counts and the soluble TNFRII levels in plasma were also determined. Of the 19 patients tested, mutant variants were observed in 2 patients (Met Val in one and Met Val & lle in second) both being treated with 3-TC. No mutations were detected in the treatment-naive patients. The results confirmed that, drug resistant variants of codon-184 emerge rapidly in patients receiving 3-TC containing regimens including our population, which is mainly infected with subtypeC of the virus that could be detected along with wild viral population using sensitive approaches such as ARMS-PCR.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Codon
/
Gènes pol
/
Infections à VIH
/
Incidence
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Numération des lymphocytes CD4
/
Inhibiteurs de la transcriptase inverse
/
Lamivudine
/
Agents antiVIH
Type d'étude:
Etude d'incidence
/
Étude pronostique
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Pathol Microbiol
Année:
2005
Type:
Article
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