Liver histology in patients on hemodialysis with chronic hepatitis C viral infection.
Indian J Pathol Microbiol
;
2008 Apr-Jun; 51(2): 182-5
Article
Dans Anglais
| IMSEAR
| ID: sea-75298
ABSTRACT
Hepatitis C virus (HCV) is a major cause of chronic liver disease in patients on hemodialysis. As no useful noninvasive predictors of disease activity and fibrosis have been found, liver biopsy is essential in these patients to accurately assess the severity of disease and thus the prognosis and plan management. The present study was undertaken to assess the degree of severity of necroinflammatory changes and fibrosis in liver biopsies of patients on hemodialysis with chronic HCV infection. Liver biopsies obtained from 45 patients on hemodialysis with serological evidence of chronic hepatitis C were studied. The grading of necroinflammatory activity and staging of fibrosis were histologically assessed. The majority of patients (30, i.e. 66.7%) had mild disease with mild inflammatory activity and stage 0, 1 or 2 fibrosis. There was no significant correlation between the degree of fibrosis and the age of the patients (rs = 0.015), the duration of hemodialysis (rs = 0.047) or the presence of steatosis (rs = 0.064). There was a positive correlation between the presence of bile ductular proliferation and the severity of fibrosis (rs = 0.612). It was concluded that chronic HCV infection in hemodialysis patients is relatively mild early in its course. However, serial follow-up liver biopsies are mandatory to plan appropriate intervention strategies.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Conduits biliaires
/
Sujet âgé de 80 ans ou plus
/
Fibrose
/
Sujet âgé
/
Femelle
/
Humains
/
Mâle
/
Enfant
/
Adolescent
/
Dialyse rénale
Limites du sujet:
Aged80
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Indian J Pathol Microbiol
Année:
2008
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS