Dysfunction of innate immunity and associated pathology in neonates.
Indian J Pediatr
;
2007 Feb; 74(2): 185-91
Article
Dans Anglais
| IMSEAR
| ID: sea-78927
ABSTRACT
The neutrophils and complement system are the critical elements of innate immunity mainly due to participation in the first line of defense against microorganisms by means of phagocytosis, lysis of bacteria and activation of naive B-lymphocytes. In this report we provide an overview of the up to date information regarding the neutrophil and complement system's functional ability in newborn infants in association with the maternal conditions that exist during the intrauterine stage, gestational age and post-neonatal pathology. The neonates' capacity to control the neutrophil and complement protein activation process has also been discussed because of the evidence that uncontrolled activation of these immune elements provides a significant contribution to the tissue damage and subsequent pathology. The authors are confident that despite the many unanswered questions this review updates their knowledge and points the need for further research to clarify the role of the age-associated dysfunction of neutrophils and complement system in the infection and inflammation related pathology of newborn infants.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Femelle
/
Humains
/
Mâle
/
Protéines du système du complément
/
Nouveau-né
/
Facteurs de risque
/
Sensibilité et spécificité
/
Immunité acquise d'origine maternelle
/
Immunité innée
/
Granulocytes neutrophiles
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Facteurs de risque
langue:
Anglais
Texte intégral:
Indian J Pediatr
Année:
2007
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS