Prevention of bronchopulmonary dysplasia: finally, something that works.
Indian J Pediatr
;
2006 Nov; 73(11): 1027-32
Article
Dans Anglais
| IMSEAR
| ID: sea-79323
ABSTRACT
Due to a lack of understanding of the molecular mechanisms involved in its pathogenesis, bronchopulmonary dysplasia (BPD) still remains a major cause of morbidity and mortality in the premature infant and there is no effective preventive and/or therapeutic intervention. We have taken a basic biologic approach to elucidate the pathophysiology of BPD and have discovered that disruption of the alveolar Parathyroid Hormone-related Protein (PTHrP) signaling is centrally involved in this process. Further, stabilization of this signaling pathway by using exogenous PTHrP agonists can prevent and/or rescue the molecular injuries caused by insults that lead to BPD. Based upon years of work in this field, here I provide a novel and innovative molecular approach, i.e, exogenous treatment with PTHrP pathway agonists to prevent and/or treat BPD. However, to avoid any later surprises, it is important to emphasize that before translating it into human trials, this approach needs further testing and refinement in animal models.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Alvéoles pulmonaires
/
Dysplasie bronchopulmonaire
/
Humains
/
Nouveau-né
/
Transduction du signal
/
Protéine apparentée à l'hormone parathyroïdienne
/
Récepteur PPAR gamma
/
Animaux
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Indian J Pediatr
Année:
2006
Type:
Article
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