Botulinum toxin in children with cerebral palsy.
Indian J Pediatr
;
2004 Dec; 71(12): 1087-91
Article
Dans Anglais
| IMSEAR
| ID: sea-80352
ABSTRACT
Botulinum toxin is a neurotoxin that blocks the synaptic release of acetylcholine from cholinergic nerve terminals mainly at the neuromuscular junction, resulting in irreversible loss of motor end plates. It is being widely tried as a targeted antispasticity treatment in children with cerebral palsy. A number of studies have shown that it reduces spasticity and increases the range of motion and is particularly useful in cases with dynamic contractures. However improvement in function has not been convincingly demonstrated. It is an expensive mode of therapy and the injections need to be repeated after 3-6 months. Whereas Botulinum toxin can be a valuable adjunct in select cases, it should not be projected as a panacea for children with spastic cerebral palsy.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Toxines botuliniques
/
Humains
/
Paralysie cérébrale
/
Enfant
/
Agents neuromusculaires
langue:
Anglais
Texte intégral:
Indian J Pediatr
Année:
2004
Type:
Article
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