NPHS2 mutations.
Indian J Pediatr
;
2008 Feb; 75(2): 135-8
Article
Dans Anglais
| IMSEAR
| ID: sea-83289
ABSTRACT
OBJECTIVE:
To uncover the frequency and the spectrum of NPHS2 mutations in Egyptian children with non familial steroid-resistant nephrotic syndrome (SRNS).METHODS:
Sixteen patients were screened by PCR-single-strand conformation polymorphism analysis of NPHS2 gene followed by direct sequencing.RESULTS:
NPHS2 mutations were evident in four patients (25%) who were bearing four novel mutations including two frame shift mutations (R238fs and P45fs) and two missense mutations (I136L and F216Y). There were no phenotypic or histological characteristics of patients bearing NPHS2 mutations, apart from the earlier onset of the disease, compared to those who were not bearing mutations.CONCLUSION:
NPHS2 mutations are prevalent in Egyptian children with non-familial SRNS and this may in part explain the less favorable prognosis reported in these patients.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Pronostic
/
Humains
/
Marqueurs génétiques
/
Enfant
/
Enfant d'âge préscolaire
/
Réaction de polymérisation en chaîne
/
Prévalence
/
Études transversales
/
Mutation avec décalage du cadre de lecture
/
Polymorphisme de conformation simple brin
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Étude pronostique
/
Facteurs de risque
Pays comme sujet:
Afrique
langue:
Anglais
Texte intégral:
Indian J Pediatr
Année:
2008
Type:
Article
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