Association of vitamin A and zinc status with altered intestinal permeability: analyses of cohort data from northeastern Brazil.
J Health Popul Nutr
;
2003 Dec; 21(4): 309-15
Article
Dans Anglais
| IMSEAR
| ID: sea-857
ABSTRACT
To examine the association of intestinal barrier function with vitamin A deficiency and whether supplementation of micronutrients improves intestinal function and/or linear growth, height-for-age z-score (HAZ), concentrations of serum retinol and zinc, and intestinal permeability were determined in a cross-sectional sample of 75 children in northeastern Brazil. Effects of vitamin A and supplementation of zinc on intestinal permeability and growth were also determined comparing results before and after treatment in 20 children and age-matched controls. Lactulosemannitol (L/M) permeability ratios inversely correlated with serum retinol concentrations (r = -0.55, p < 0.0005). Increased L/M permeability ratios with reduced concentrations of serum retinol were predominantly attributable to lower absorption of mannitol (r = 0.28, p = 0.02). L/M permeability ratios (p = 0.001) and HAZ scores (p = 0.007) improved with supplementation. It is concluded that impaired intestinal barrier function and linear growth shortfalls improve following supplementation of vitamin A and zinc in this setting.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Rétinol
/
Carence en vitamine A
/
Zinc
/
Brésil
/
Femelle
/
Humains
/
Mâle
/
Nouveau-né
/
Perméabilité capillaire
/
Phénomènes physiologiques nutritionnels chez l'enfant
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Facteurs de risque
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
J Health Popul Nutr
Thème du journal:
Gastroenterology
/
Nutritional Sciences
/
Public Health
Année:
2003
Type:
Article
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