Effect of intraesophageal acid instillation on airway reactivity in patients with asthma.
Article
Dans Anglais
| IMSEAR
| ID: sea-86606
ABSTRACT
OBJECTIVE:
To study the change in airway reactivity due to presence of acid in lower esophagus and its reversibility by antacid.METHOD:
In this double blind study 12 subjects with asthma and gastroesophageal reflux received acid (N/10 hydrochloric acid) and antacid (mixture of magnesium trisilicate and aluminum hydroxide) perfusion in lower esophagus via a nasogastric tube. The four combinations were antacid-antacid (control), antacid-acid, acid-antacid and acid-acid. Airway reactivity (Histamine PD20) was recorded after each perfusion.RESULTS:
Histamine PD20 significantly decreased (airway reactivity increased) (p < 0.05) with all three combinations containing acid as compared to control. No significant difference in airway reactivity was observed if the antacid was given before or after the acid.CONCLUSION:
Presence of acid in lower esophagus can increase airway reactivity. This effect lasts longer than the presence of acid in esophagus itself.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Asthme
/
Tests de provocation bronchique
/
Femelle
/
Humains
/
Mâle
/
Reflux gastro-oesophagien
/
Volume expiratoire maximal par seconde
/
Méthode en double aveugle
/
Adolescent
/
Hyperréactivité bronchique
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Année:
2000
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS