Exjade (ICL 670): A new oral iron chelator.
Article
Dans Anglais
| IMSEAR
| ID: sea-87506
ABSTRACT
ICL670(deferasirox) is a tridentate oral iron chelator that has shown high efficacy and theraputic safety in preclinical and currently ongoing phase III clinical evaluation. The drug has been just approved by US FDA for use in iron-loading anaemias. It is an ideal once-daily oral chelator, the effective dose of which is between 20 and 40 mg/kg. Iron is chelated & excreted almost exclusively via the feces. This is a major advance in the field of iron chelation.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Triazoles
/
Benzoates
/
Humains
/
Essais contrôlés randomisés comme sujet
/
Agents chélateurs du fer
/
Administration par voie orale
/
Bêta-Thalassémie
/
Maquettes de structure
Type d'étude:
Essai clinique contrôlé
langue:
Anglais
Année:
2006
Type:
Article
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