Effect of calcium channel antagonists on cholinergic bronchial responsiveness in asthma.
Article
Dans Anglais
| IMSEAR
| ID: sea-88710
ABSTRACT
Bronchial responsiveness to methacholine was studied in 23 stable asthmatics before and after nifedipine and diltiazem. There was no significant bronchodilatory effect of either calcium channel antagonists. The mean provocative dose of methacholine required to produce a 20% fall in FEV1 (PC20 = 0.157 +/- 0.74 mg) was not altered by nifedipine (PC20 = 0.159 +/- 0.61). However, diltiazem offered significant protection. The mean ratio of PC20 after diltiazem over baseline was 3.27 +/- 3.55. The results suggest that although both calcium channel antagonists have no influence on normal basal bronchomotor tone, diltiazem does significantly protect against cholinergic stimulation.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Asthme
/
Tests de provocation bronchique
/
Humains
/
Inhibiteurs des canaux calciques
/
Diltiazem
/
Nifédipine
/
Bronchoconstriction
/
Chlorure de méthacholine
/
Hyperréactivité bronchique
langue:
Anglais
Année:
1993
Type:
Article
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