Food reduces isoniazid bioavailability in normal volunteers.
Article
Dans Anglais
| IMSEAR
| ID: sea-89466
ABSTRACT
Food and drug interaction is a major variable in bioavailability of drugs. Isoniazid is the most common antitubercular drug used in India. We studied the effect of standard Indian breakfast and lunch on the bioavailability of isoniazid in a single dose crossover study in normal male volunteers. The standard breakfast and lunch significantly reduced plasma AUC, Cmax and Kabs values of isoniazid. Isoniazid, thus, should not be administered with food.
Texte intégral:
Disponible
Indice:
IMSEAR (Asie du Sud-Est)
Sujet Principal:
Humains
/
Mâle
/
Biodisponibilité
/
Adulte
/
Aliments
/
Isoniazide
langue:
Anglais
Année:
1991
Type:
Article
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